Supplementary Materials Supplementary Table S1: Comparison of Outcomes, Clinical Characteristics, and Laboratory Findings Between Male and Female Patients Supplementary Table S2: Univariate Analysis, Stratified According to Sex JGS-9999-na-s001

Supplementary Materials Supplementary Table S1: Comparison of Outcomes, Clinical Characteristics, and Laboratory Findings Between Male and Female Patients Supplementary Table S2: Univariate Analysis, Stratified According to Sex JGS-9999-na-s001. were used to explore risk factors for death. RESULTS Univariate analysis revealed that several clinical characteristics and laboratory variables were significantly different (ie, = .001) and older age (OR = 1.122; 95% CI = 1.007\1.249; = .037) were independently associated with hospital mortality. White blood cell count was also an important risk factor (= .052). The area under the receiver operating characteristic curve in the Rabbit Polyclonal to GDF7 logistic regression model was 0.913. Risk factors for in\hospital death were comparable between older men and women. CONCLUSION Older age and lower LYM count on admission were associated with death in hospitalized COVID\19 patients. Stringent monitoring and early intervention are needed to reduce mortality in these patients. values were .05. RESULTS A total of 244 older patients with a definite clinical outcome recorded by March 5, 2020, were enrolled in the study, including 123 who were discharged and 121 who died (Table ?(Table1).1). The median age of the discharged patients was 67?years, while TP-434 enzyme inhibitor that of the deceased group was 72?years (= TP-434 enzyme inhibitor .042). While 16.7% of deceased patients had a history of respiratory problems, only 3.3% of the discharged patients had a history of respiratory problems (Value= .037; and OR = 0.009; 95% CI = 0.001\0.138; = .001, respectively), indicating that older age and lower LYM count on admission were independently associated with increased risk for death. In addition, WBC count exhibited a value of .052 (OR = 1.28; 95% CI = 1.00\1.64). The results of logistic regression and the impartial risk factors (ie, age and LYM count) were used to generate ROC curves (Physique ?(Figure1).1). The area under the ROC curve in the logistic regression model was 0.913, and that for age and LYM count were 0.653 and 0.823, TP-434 enzyme inhibitor respectively, indicating that LYM count and age were the most important risk factors for death. Table 2 Multivariate Analysis of Risk Factors for Mortality Value= .401) and may be more predictive among younger patients. Due to the absence of data, IL\6 could not be included in the logistic regression analysis. Fever and dry cough were the most common symptoms in patients with COVID\19. Moreover, gastrointestinal symptoms were experienced by 33.2% of the patients in our study. For older patients with coronary heart disease and diabetes, mortality may not increase if complications are well controlled. Patients with hypertension also exhibited poorer outcomes (= .042). A recent study reported that angiotensin\converting enzyme 2 (ACE2) may be the host receptor for SARS CoV\2. 14 Many models of hypertension are associated with reduced ACE2 expression, 15 indicating a plausible relationship between hypertension and COVID\19. As commonly used antihypertensive drugs, ACE inhibitors and angiotensin II receptor blockers can upregulate ACE2 expression while reducing blood pressure.16, 17 Therefore, antihypertensive drugs should be cautiously used in patients with COVID\19, and further studies are needed to establish the relationship between hypertension and COVID\19. Previous respiratory disease was significantly associated with death due to COVID\19 ( em P /em ? ?.001), indicating that older patients with previous respiratory disease often have a poorer prognosis after contamination with SARS CoV\2. Sex was statistically different in our univariate analysis, and older men exhibited a worse outcome than older women. Some studies indicated that SARS CoV\2 was more likely to infect males, which may be related to the high expression of ACE receptors in the lung tissues of Asian men. Other studies.

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