Background To explore the prognostic performance of coronary computed tomography angiography

Background To explore the prognostic performance of coronary computed tomography angiography (CCTA) and exercise electrocardiography (XECG) in asymptomatic subjects. using XECG may demonstrate important for OSI-930 identifying asymptomatic subjects who can benefit from CCTA. ideals for 2 according to the likelihood-ratio test are also offered). A time-dependent receiver operating characteristic (ROC) curve was constructed to compare the global concordance probability between medical risk factors (i.e., foundation model) versus medical risk factors plus CAD recognized by CCTA model. A value less than 0.05 was considered statistically significant in all analyses. Statistical analyses were performed using SPSS version 15 software (SPSS Inc., Chicago, IL, USA) and R software version 3.20. Results Clinical characteristics of study population Overall, the study population consisted of 812 asymptomatic subjects (mean age 59 9 years, 60.8% male) (Table 1). Subjects who experienced CAD determined by CCTA were older (62 8 vs. 58 9, < 0.001) and comprised more male subjects (77.5% vs. 57.3%, < 0.001) and history of diabetes mellitus (33.1% vs. 18.1%, < 0.001) than subjects without CAD by CCTA. Subjects who had more than two medical risk factors (i.e., hypertension, diabetes mellitus, dyslipidemia, and current smoking) made up 39.7% of the total study population (n = 322). Reasons for undergoing CCTA included subjects presenting with medical risk factors (n = 468, 57.6%), part of a general health evaluation (n = 223, 27.5%), abnormal resting ECG (n = 91, 11.2%), or preoperative evaluation (n = 30, 3.7%). Table 1 Baseline characteristics XECG and CCTA results Among the study cohort, 120 subjects (14.8%) had a positive XECG result and 273 subjects (33.6%) were classified as moderate-to-high-risk according to DTS (Table 2). The proportion of positive XECG and value of METs did not differ between subjects with or without CAD by CCTA (all > 0.05). In NSD2 contrast, a higher number of subjects with CAD were classified into the moderate-to-high-risk group according to DTS, which was significant (46.5% vs. 30.9%, < 0.001). By CCTA, 142 subjects (17.5%) had obstructive CAD: 1-VD (n = 111, 13.7%), 2-VD (n = 28, 3.4%), or 3-VD (n = 3, 0.4%). In terms of the severity of CAD, subjects were classified as having slight (n = 271, 33.4%), moderate (n = 148, 18.2%), and severe (n = 30, 3.7%) CAD (Table 3). The overall agreement for subjects who experienced positive or bad results in both XECG and CCTA and between XECG and CCTA was 74.4% (576 from 774 subjects, excluding subjects with equivocal XECG results). Most subjects with positive XECG results experienced no CAD as determined by CCTA (n = 92, 76.7%), while 6 subjects (5.0%) with positive XECG results had multi-VD (n = 6, 5.0%) or severe stenosis (n = 4, 3.3%) in CCTA. Table 2 Results of XECG in relation to CCTA Table 3 Results of CCTA in relation to DTS For 92 individuals with fake positive XECG outcomes, the mean age group was 58 8 years, and 42.4% were ladies, which showed no factor from total research population. Long-term medical outcomes Throughout a OSI-930 mean follow-up of 37 16 weeks, 9 topics (1.1%) experienced MACE-all revascularization (Desk 4). Individuals determined to get CAD had been followed-up regularly, and 4 of these underwent intrusive coronary angiography within 3 months from CCTA. All 9 individuals who experienced MACE underwent intrusive coronary angiography because of new onset steady angina, and stenoses OSI-930 needing revascularization had been found through the treatment. The mean time and energy to MACE was 20 13 weeks. The incidence of MACE based on the total results of XECG and CCTA is shown in Table 5. Most topics who experienced MACE (n = 8) got CAD by CCTA and everything revascularized lesions had been previously determined by.

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