Background To investigate the reproducibility of macular ganglion cell-inner plexiform layer

Background To investigate the reproducibility of macular ganglion cell-inner plexiform layer (GCIPL) thickness measurement in normal eyes determined by different operators and two different raster scanning protocols of Cirrus high-definition optical coherence tomography (HD-OCT). ICCs of Macular Cube 512??128 and 200??200 protocol were 0.953 to 0.987 and 0.953 to 0.991, respectively; and the inter-protocol ICCs Epirubicin Hydrochloride novel inhibtior were 0.876 to 0.991. All CoVs were 1.5%. Conclusions Cirrus HD-OCT can measure macular GCIPL thickness in normal eyes with excellent reproducibility. The measurements determined by Macular Cube 512??128 and 200??200 protocol were highly consistent and both protocols were eligible for macular GCIPL thickness measurement. value 0.05 was considered statistically significant. Results A total of 108 participants were enrolled in the study based on the inclusion criteria. Of these, 6 participants were excluded because of segmentation failure of the OCT images. Thus, the analyses within this research had been predicated on data from 102 topics (52 men and 50 females). The topics ranged in age group from 19 to 75?years (mean, 46.0??16.2?years). The IOP ranged from 9 to 19?mmHg (14.3??2.5?mmHg). The spherical exact carbon copy of refractive mistake ranged from ?5.25 to +2.00 D (?0.57??1.88 D). The mean Epirubicin Hydrochloride novel inhibtior deviation from the visible field tests ranged from ?2.05 to at least one 1.74?dB (?0.77??0.84?dB). Mean beliefs of the common, minimum, excellent, superonasal, inferonasal, second-rate, inferotemporal, and superotemporal macular GCIPL width measured by both operators had been displayed in Desk ?Desk1.1. There is no factor from the three repeated measurements from the GCIPL width variables by each operator, as well as the difference from the GCIPL width measured Epirubicin Hydrochloride novel inhibtior by both operators also demonstrated no statistical significance (all worth 0.05). Desk ?Desk22 showed the intra- and inter- operator ICC for GCIPL width measurements, which the cheapest and highest information were the common GCIPL width and least GCIPL width, respectively. Desk 1 Goat polyclonal to IgG (H+L) GCIPL thickness (Mean??SD, m) measured by two operators using macular cube 512??128 scanning protocol intraclass correlation coefficient, confidence interval, coefficients of variation Mean values of the average, minimum and sectorial GCIPL thickness determined by Macular Cube 512??128 and Macular Cube 200??200 scanning protocols were displayed in Table ?Table3.3. There was no significant difference of the three repeated measurements of the GCIPL thickness determined by each protocol, and the differences of the GCIPL thickness determined by the two protocols also showed no statistical significance (all value 0.05). However, the average signal strength of Macular Cube 512??128 and Macular Cube 200??200 scanning protocols was 8.54??1.13 and 7.60??1.06, respectively. The difference between each protocol was statistically significant (intraclass correlation coefficient, confidence interval, coefficients of variation Table 5 The correlation of mean signal strength and coefficient of variation (CoV) of repeated measurements of GCIPL thickness obtained by two macular cube scanning protocols thead th rowspan=”1″ colspan=”1″ /th th colspan=”2″ rowspan=”1″ Macula Cube 512??128 Protocol /th th colspan=”2″ rowspan=”1″ Macula Cube 200??200 Protocol /th th rowspan=”1″ colspan=”1″ Parameter /th th rowspan=”1″ colspan=”1″ em r /em a /th th rowspan=”1″ colspan=”1″ em P /em /th th rowspan=”1″ colspan=”1″ em r /em a /th th rowspan=”1″ colspan=”1″ em P /em /th /thead Common?0.2610.008?0.2100.034Minimum?0.2430.014?0.372 0.001Superotemporal?0.1790.072?0.2080.036Superior?0.0640.5250.0290.774Superonasal?0.1350.176?0.0430.669Inferonasal?0.2800.004?0.1860.062Inferior0.0250.805?0.2930.003Inferotemporal?0.0490.627?0.2880.003 Open in a individual window aPearsons correlation coefficient Discussion In this study, we evaluated the intra- and inter-operator reproducibility of macular GCIPL thickness measurement and investigated the reproducibility of the two available raster scanning protocols of the Cirrus HD-OCT in a Chinese population. Generally, we confirmed that this Cirrus HD-OCT could measure macular GCIPL thickness Epirubicin Hydrochloride novel inhibtior in normal eyes with excellent reproducibility. In our study, all ICCs of the macular GCIPL thicknesses ranged between 0.875 and 0.992, and the CoVs were 1.5%. The ICCs were highest for the common GCIPL and most affordable for the minimal GCIPL thickness. These results had been based on the previous results. Choi et al. seen the reproducibility of macular GCIPL thicknesses in 44 glaucoma sufferers. The ICCs had been between 0.96 and 0.99, as well as the CoVs were 3% [5]. In 50 glaucoma sufferers, Mwanza et al. discovered that all intervisit ICCs ranged between 0.94 and 0.98 as well as the CoVs were 5% [6]. Our outcomes.

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