Supplementary MaterialsSI. 6.6 Hz, 2H), 2.24 (s, 3H). 13C NMR (CDCl3, 75 MHz): 159.1, 136.3, 131.9, 131.1, 129.7, 128.4, 128.2, 123.4, 117.7, 113.6, 88.3, 85.3, 59.3, 57.8, 55.4, 37.8 ppm. IR (thin film): 2948, 2834, 2786, 1642, 1609, 1583, 1507, 1488, 1441, 1301, Calcipotriol cell signaling 1244, 1169, 1126, 1107, 1033, 994, 962, 916, 850, 807, 778, 754, 689, 583, 524 cm?1. HRMS (ESI-TOF) = 0.75 (6:4 hexanes/EtOAc). 1H NMR (CDCl3, 500 MHz): 7.65C7.61 (m, 2H), 7.59C7.56 (m, 2H), 7.40C7.34 (m, 5H), 5.90C5.91 (m, 1H), 5.35 (dd, = 17.0 Hz, 2.0 Hz, 1H), 5.23 (dd, = 10.5 Hz, 2.0 Hz, 1H), 4.98 (s, 1H), 3.21 (d, = 6.0 Hz, 2H), 2.26 (s, 3H). 13C NMR (CDCl3, 125 MHz): 137.5, 135.9, 133.3, 131.8, 129.8, 128.4, 128.3 (2), 122.9, 117.9, 88.7, 84.2, 59.1, 57.8, 37.6 ppm. IR (thin film): 1487, 1442, 1402, 1089, 1014, Calcipotriol cell signaling 994, 962, 920, 853, 796, 689, 592, 582 cm?1. HRMS (ESI-TOF) = 0.68 (6:4 hexanes/EtOAc). 1H NMR (CDCl3, 500 MHz): 7.43 (d, = 8.5 Hz, 2H), 6.86 (d, = 8.5 Hz, 2H), Calcipotriol cell signaling 5.84C5.81 (m, 1H), 5.23 (dd, = 17.0 Hz, 1.5 Hz, 1H), 5.12 (d, = 6.5 Hz, 1H), 4.62 (s, 1H), 3.04 (t, = 7.5 Hz, 2H), 2.10 (s, 3H), 1.40C1.32 (m, 1H), 0.84C0.80 (m, Calcipotriol cell signaling 2H), 0.75C0.71 (m, 2H) ppm. 13C NMR (CDCl3, 125 MHz): 159.1, 136.6, 131.7, 129.7, 117.5, 113.5, 91.7, 77.5, 59.0, 57.7, 55.5, 37.8, 8.8, 0.2 ppm. IR (slim film): 1610, 1507, 1361, 1243, 1109, 1035, 1016, 999, 918, 982, 850, 808, 777, 584 cm?1. HRMS (ESI-TOF) [M + H]+ = 0.75 (6:4 hexanes/EtOAc). 1H NMR (CDCl3, 500 MHz): 7.59 (d, = 8.5 Hz, 2H), 7.55C7.54 (m, 2H), 7.53C7.51 (m, 3H), 6.89 (d, = 8.5 Hz, 2H), 5.90C5.83 (m, 1H), 5.27 (d, = 17.0 Hz, 1H), 5.14 (d, = 10.0 Hz, 1H), 5.05 (s, 1H), 3.82 (s, 3H), 3.28 (dd, = 14.0 Hz, 2.0 Hz, 2H), 3.04 (dd, = 14.0 Hz, 8.0 Hz, 2H) ppm. 13C NMR (CDCl3, 125 MHz): 159.1, 136.8, 132.1, 132.0, 131.6, 129.6, 128.5, 128.3, 123.6, 117.5, 113.7, 88.9, 85.9, 56.2, 55.5, 53.7 ppm. IR (thin film): 1609, 1508, 1489, 1447, 1301, 1246, 1170, 1108, 1036, 995, 971, 919, 848, 811, 759, 691 cm?1. HRMS (ESI-TOF) [M + H]+ = 0.74 (6:4 hexanes/EtOAc). 1H NMR (CDCl3, 500 MHz): 7.47C7.44 (m, 2H), 7.32C7.29, (m, 3H), 5.88 (ddt, = 6.0 Hz, 10.5 Hz, 17.0 Hz, 1H), 5.27 (d, = 17.0 Hz, 2H), 5.17 (d, = 10.5 Hz, 2H), 3.23 (dd, = 5.0 Hz, 13.5 Hz, Calcipotriol cell signaling 1H), 3.19 (d, = 9.0 Hz, 1H), 2.91 (dq, = 16.5 Hz, 6.5 Hz, 1H), 1.13 (d, = 6.5 Hz, 3H), 1.05 (d, = 6.5 Hz, 3H) ppm. 13C NMR (CDCl3, 125 MHz): 136.2, 131.7, 128.4, 128.2, 127.8, 123.6, 117.4, 86.4, 63.2, 58.2, 37.8, 31.0, 20.8, 19.9 ppm. IR (slim film): 1952, 1643, 1598, 1488, 1443, 1412, 1383, 1364, 1326, 1261, 1208, 1163, 1096, 1069, 1027, 995, 917, 753, 689, 595, 545 cm?1. HRMS (ESI-TOF) [M + H]+ = 0.44 (6:4 hexanes/EtOAc). 1H NMR (CDCl3, 500 MHz): 7.33 (d, = 8.3 Hz, 2H), 7.09 (d, = 8.3 Hz, 2H), 5.89 (ddt, = 4.0 Hz, 6.5 Hz, 10.3 Hz, 1H), 5.25 (d, = 17.5 Hz, 1H), 5.17 (d, = 10.3 Hz, 1H), 3.54 (s, 1H), 3.14 (d, = 6.5 Hz, 2H), 2.38 (s, 3H), 2.33 (s, 3H) ppm. 13C NMR (CDCl3, 125 MHz): 138.1, 135.1, 131.6, 129.0, 120.1, 118.3, 85.6, 83.3, 59.1, 46.0, 41.6, 21.4 ppm. IR (thin film): 2918, 1787, 1643, 1509, 1449, 1359, 1325, 1254, 1193, 1128, 1107, 1032, 994, 968, 921, 814, 677, 629, 566 cm?1. HRMS (ESI-TOF) [M + H]+ = 0.22 (2:1 hexanes/EtOAc). 1H NMR (CDCl3, 300 MHz): 7.54C7.48 (m, 4H), 7.33C7.31 (m, 3H), 6.9 (d, = 8.7 Hz, 2H), 5.18 (s, 1H), 3.81 (s, 3H), 2.56 (s, 3H), 1.81 (s, 1H) ppm. 13C NMR (CDCl3, 75 MHz): 159.2, 132.4, 131.7, 128.8, 128.3, 128.1, 123.1, 113.8, 89.2, 85.5, 55.6, 55.3, 33.7 ppm. IR (thin film): 2953, 2834, CD244 2790, 1609, 1584, 1508, 1488, 1462,.